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Weight fluctuations on levothyroxine are typically due to under-treatment or over-treatment rather than the medication itself. Indeed, its not the levothyroxine that can cause weight gainits the condition for which people are taking it, which is hypothyroidism, or underactive thyroid
In particular, fibrosarcoma, a typical tumor with a little-known relationship with the ovary, can increase plasma CXCL10, which reaches the ovaries, binds to IL18R1 on the ovaries, and triggers multiple downstream ovary-disrupting signals
Dietary approaches produce much more modest effects than prescription GLP-1 medications
Pang et al