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The process of zonation occurs throughout postnatal development, with GS being specifically absent from fetal liver hepatocytes 38 and only detectable in the liver parenchyma after Day 2 post partum in humans 38

A CobaSorb test showing a clear increase in holoTC supports a normal uptake, while an increase below a set limit should be taken with some reservation before a conclusion of a permanent impaired uptake of B12 is made