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Most of the calcium present in the body is in the form of Ca 2+ ions, complexes, and inorganic salts ( 6.1 Role of calcium ions in insulin secretion from pancreatic cells In islet beta cells, glucose-induced rapid increase of Ca 2+ is a central signaling messenger that triggers insulin secretion ( + channel (KATP) membranes to depolarize closure and voltage-dependent Ca 2+ channels to open, promote Ca 2+ influx, and bind cations to gelsolin and synaptotagmin, which are conducive to cortical actin (limiting but not preventing vesicles from entering the plasma membrane) and membrane fusion, respectively ( 6.2 Disturbed calcium homeostasis in diabetes 6.2.1 Diabetes and hypocalcemia Diabetic patients have impaired renal function due to hypovolemia