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Barron JL, Hopkins KD, Dunger DB, Hesp R, White A

MOTS-c Primary focus: Mitochondrial metabolism Insulin sensitivity Metabolic aging in women MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is encoded in mitochondrial DNA not the nuclear genome and functions as a mitochondrial-derived peptide that communicates metabolic stress signals systemically

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ENS neurotransmitters are also tied directly to the regulation of intestinal barrier functions, which control both the gut microbiota composition and immune responses