A gentle hand is required to preserve the fragile structure of the peptide
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By regulating the unpolymerized actin pool, TB-500 acts as a rheostat for cytoskeletal remodeling : on migration or repair signals, sequestered G-actin is released and polymerized at the leading edge of moving cells
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We discuss how copper also plays a key role in proteostasis and interacts either directly or indirectly with many of the key aggregate-prone proteins implicated in ALS, such as TDP-43, C9ORF72, SOD1 and FUS as well as the effect of their aggregation on copper homeostasis