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In an open-label, phase 3, multicenter study involving 11 children aged 25 years with biallelic POMC, PCSK1, or LEPR variants, or genetically confirmed BardetBiedl syndrome (BBS), 83% achieved a 0.2-point reduction in BMI Z score over 52 weeks, with a mean BMI reduction of 18% observed overall (26% in the POMC/LEPR group and 10% in the BBS group) [45]

Simply input the required values, and youll receive precise dosing calculations

That additional 7-14 percentage points over semaglutide comes from the glucagon receptor activation, which drives increased energy expenditure through a mechanism that the other two peptides simply do not have

Understanding these potential pathways helps contextualise the symptom and guides appropriate management strategies

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