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Potential risks of HRT include coronary artery disease, blood clots, stroke, and certain cancers

First, preclinical studies indicate that GLP-1R activation can reduce excitatory synaptic input onto VTA dopamine neurons and suppress intake of highly rewarding foods (5658)

Furthermore, our study provides a validated framework for ranking DM2 DMTs based on their predicted impact within the DM2-AD comorbidity network, offering a data-driven approach to identify therapies with the highest potential for AD prevention

Additional symptoms including fatigue, cold intolerance, and reduced physical activity further compound weight management difficulties

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