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Innovations introduced longer-acting formulations: semaglutide (novel peptide with fatty acid modifications) enabled once-weekly dosing and was first approved as Ozempic (T2D, 2017) and then as Wegovy (obesity, 2021)

2010 Jul;118(7):928-35

The evidence as presented provides the rationale to further investigate this naturally occurring peptide in preclinical and clinical aging studies

Observational studies have associated alterations in cortisol patterns, such as flattened diurnal curves or elevated evening levels, with obesity, metabolic syndrome, and cardiovascular risk, though these findings do not establish causality

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