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CV outcome trials demonstrated reductions in atherothrombotic events, especially in patients with established atherosclerosis 13

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In that lower-insulin context, GIP may support healthier fat tissue function, improve adiponectin, reduce adipose hypoxia, and allow higher GLP-1 activity with better tolerability.The practical takeaway is that tirzepatide should not be viewed as a magic weight-loss injection or a permanent substitute for lifestyle change