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Tetelbaun et al.)

MR Spectroscopy Metabolites of interest were glutamate, glutamine, glutathione, and GABA, and were measured in two voxels, one placed bilaterally in the dorsal anterior cingulate cortex (dACC, 35x40x20 mm 3 ) and one in occipital cortex (OC, 30x30x30 mm 3 at 3 T, 28 28 28 mm 3 at 7 T)

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The clinical sites, sample sources (CENTER TBI [31, 41] and the CanTBI bank [30]), severity of TBI, health status of controls, time points and methods for characterizing lipid metabolism varied between trials and contributed to the observed differences

Longer-term safety and efficacy data from Phase 3 trials are essential before any licensing decision can be made