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These harmful agents are a result of our skins exposure to UV exposure and environmental pollutants

Other proteins that bind KEAP1 and interfere with KEAP1-NRF2 interaction, promoting NRF2 accumulation and function in the nucleus, include: phosphoglycerate mutase 5 (PGAM5, a serine/threonine phosphatase related to the phosphoglycerate mutase family), which has been reported to be associated with mitochondria, so its interaction with KEAP1 may be regulated by mitochondrial signalling processes [187, 188]

doi: 10.3945/jn.110.123273

doi: 10.1038/s41423-023-01053-6 318 SilvinA.UderhardtS.PiotC.Da MesquitaS.YangK.GeirsdottirL.et al