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But having a defective ade2 gene turns yeasts red if they have not divided for some time because they have accumulated red pigments - these are by-products of the not-fully-repressed and defective adenine-biosynthesis

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Red areas indicate increased cFOS activity and blue areas indicate decreased cFOS activity

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We found that normal astrocytes (HEB) showed higher tolerance to the combination treatment of metformin and simvastatin compared to glioma cells (U87, T98G) (Fig