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Saxenda was the first GLP-1 medication to get approval from the FDA for weight management in adults with obesity and overweight with at least one weight-related health condition as an adjunct to exercise, and lifestyle and dietary modifications

However, those with advanced CKD should consult a doctor first

The molecule was engineered through rational drug design to create a single peptide capable of activating both GIP and GLP-1 receptors with therapeutic potency

So much about drug pricing is still to opaque and disconnected from long-term outcomes

In the SURPASS trials, malignant neoplasms were reported at rates similar to those observed with comparator agents including placebo, insulin, and other GLP-1 receptor agonists