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A high positive titer serves as an important prognostic indicator, as patients with anti-CCP antibodies are at an increased risk for more severe, rapidly progressive, and erosive joint damage compared to seronegative patients (Shmerling & Greisen, 2025)

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It has also been observed a correlation between high levels of GSTP1-1 in the brain and medical intractability, suggesting that the enzyme may contribute to resistance to antiepileptic drug treatment 62

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