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Metformin is commonly used as first-line therapy unless contraindicated or poorly tolerated, but the addition of glucose-lowering therapies with different mechanisms of action is usually needed to provide adequate glycemic control [1,2,3], with the choice of agent being dependent on multiple factors, such as cost and the presence of comorbidities [1]

Numerous patients meet the criteria for irritable bowel syndrome with constipation (IBS-C) or psychological disorders

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Pregnant and breastfeeding women should seek medical advice, although many probiotic strains are considered safe during pregnancy