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During 1,414,144 person-years of follow-up, cholangiocarcinoma occurred among 222 patients with use of DPP4 inhibitors (incidence rate, 26 per 100,000 patient-years) and among 128 patients with use of sulfonylureas (incidence rate, 23 per 100,000 patient-years)

Patients taking both medication classes require appropriate monitoring and should be educated about recognizing signs of bleeding complications

doi: 10.3389/fimmu.2017.01734 9 NagaeKUchiHMorino-KogaSTanakaYOdaMFurueM

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Advantage : Semaglutide Summary and Verdict# Ecnoglutide's biased GLP-1 signaling represents a scientifically novel approach, and SLIMMER Phase 3 data (15.4% weight loss at 48 weeks) are comparable to semaglutide's STEP 1 results (14.9% at 68 weeks)