each R 4 is independently selected from F, Br, I, CN, NO 2 , OR 9 , OCF 3 , NR 8 R 9 , C(O)NR 8 R 9 , N(R 8 )C(O)R 10 , N(R 8 )CO 2 R 10 , NHS(O) 2 R 10 , S(O) 2 NR 8 R 9 , C 2 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 heteroalkyl, C 2 -C 7 heterocycloalkyl, C 6 -C 10 aryl, and C 3 -C 9 heteroaryl
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Notably, increased expression of C/EBP promotes the expansion of PMN-MDSCs while inhibiting the differentiation of M-MDSCs, which are more prevalent in tumors and exhibit higher immunosuppressive activity [83]
International Journal of Plant, Animal and Environmental Sciences 5(1):5661 Raghavendra M, Ravindra RK, Raghuveer YP, Narasimha JK, Uma MR, Navakishor P (2016) Alleviatory effects of hydroalcoholic extract of cauliflower (Brassica oleracea var