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2 Additional analysis showed that lean mass accounted for no more than 10.8% of change in total tissue mass at the highest dose, indicating that weight loss was primarily driven by reductions in fat mass

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There was a steady rise in the use of these drugs in these countries, especially GLP-1R agonists in the U.S., in the periconceptional period

253 Although more than a third of these defects were related to multiple pregnancies, the remainder were considered to be direct effects of assisted reproductive techniques