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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility

They identified that SUMOylation of CD45 reduced its phosphatase activity, consequently enhancing STAT3 activation and contributing to the immunosuppressive nature of MDSCs [155]

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