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Indeed, MS affects three times more women than men, but appears to follow a less aggressive course in women (Confavreux and Vukusic, In vitro experiments and preclinical studies also support the hypothesis that sex hormones may improve remyelination (for a review, see El-Etr et al., It therefore appears likely that several mechanisms and factors contribute to impaired remyelination, ranging from genetic background to neuropathological subtype
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