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Studies have shown that mice with mutations in the colony-stimulating factor 1 gene, which causes monocyte/macrophage dysfunction, have reduced blood pressure elevation and vascular injury when exposed to Ang II or DOCA (deoxycorticosterone acetate) and salt [231, 232]
This increased scrutiny has culminated in the ban of propylparaben in oral products per California law, set to go into effect January 2027
These side effects differ from other supplement-related digestive issues because they're primarily related to water retention rather than irritation or allergic reactions
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