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This single event triggers three major downstream signaling pathways that collectively govern neuronal health: the MAPK/ERK pathway, the PI3K/Akt pathway, and the PLCgamma pathway

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Western blot after co-IP revealed that both endogenous Taf12L-FLAG, as well as P TET expressed Taf12L-FLAG can very specifically pull down only Ada1 but not Taf4 (Figure 1E