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In addition, the phase 3 SURPASS2 trial, which compared efficacy and safety of tirzepatide and semaglutide among people with T2D, with or without obesity, reported a mean difference in bodyweight change from baseline at week 40 between tirzepatide (15 mg) and semaglutide (1 mg) of 6.2 kg (efficacy estimand)

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Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice