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The hip (proximal femur) and vertebrae have a large proportion of trabecular bone which can lose density rapidly in osteoporosis, whereas cortical-rich bones like the skull or arms may lose density more slowly or later

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For the cerebrovascular uptake study ( n = 22), male and female homozygous APOE2-, APOE3-, and APOE4-TR mice were euthanized at 26-weeks (Supplementary Table S2)