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Probiotics act on epithelial and immune cells in two manners: one is direct probiotic contact with epithelial and immune cells via microbe-associated molecular patterns (MAMPs) such as microbial conserved molecules like surface proteins (SLPs), Lipoteichoic acid (LTA), flagellins, pilins, capsular polysaccharides (CPSs), peptidoglycan (PGN) and lipopolysaccharides (LPS), which may be sensed by host immune receptors to mediate such interactions (57)

MGO can also induce apoptosis of islet cells, increase fasting plasma glucose levels and impair glucose tolerance (98)