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However, GLP-1 is also produced by enteroendocrine L-cells and by PPG neurons of the lower brainstem

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This makes it particularly harmful because it: delivers fatty acids directly to the liver worsens liver insulin resistance drives inflammation drives up sdLDL that cannot easily be removed by LDL receptors (and is principle cause of coronary artery disease) accelerates cardiovascular disease Visceral fat becomes both a marker of metabolic overload and a driver of further damage