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Liu Y, Yin C-Y, Zhu L-J, Zhu X-H, Xu C, Luo C-X, et al Sucrose preference test for measurement of stress-induced anhedonia in mice

A 2014 review in the peptide impurity literature, surveying SPPS-related failure modes across commercial peptide drugs, notes that these impurities accumulate through the synthesis because each flawed coupling gets carried forward on the resin