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In the multivariable Cox proportional hazard regression model adjusted for sex, age, marital status, duration of diabetes, hemoglobin A1c, estimated glomerular filtration rate, cardiovascular disease, use of insulin, use of cholesterol lowering medicine, and use of blood pressure lowering medicine, exposure to once-weekly semaglutide also was independently associated with a higher risk of upcoming NAION (HR 219, 95% CI 154 312)

The available discussion of semaglutide headache duration also emphasizes that individual experiences vary

The sensitivity analysis based on risk of bias was not performed because only a few trials were at high risk of bias, while the average risk of bias across treatment comparisons was incorporated into our assessment of confidence in the findings using the CINeMA framework [25]

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None of those are dealbreakers on their own, but they are exactly the kind of details worth nailing down with Zevay's support team directly before you commit to a subscription and a medication decision