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Meanwhile, the brand companys real defense perimeter extends far beyond whatever the Orange Book currently displays: continuation applications still in prosecution at the USPTO, unmarked foreign patents with potential domestic relevance, pediatric exclusivity extensions triggered by FDA Written Requests that the database never captures, and price-negotiation timelines under the Inflation Reduction Act that change the calculus on whether defending a patent at all is commercially rational

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Previous experimental findings have indicated that exposure to PS-MPs (30 mg/kg) leads to a marked reduction in the PBE rate of mouse oocytes

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