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Psychostimulants have been reported to induce long-term extracellular and intracellular neurochemical damage primarily via glutamate-mediated pathways in dopaminergic reward systems, thereby modifying neuronal viability and neuroplasticity [31]

2.2 Neurotoxic mechanisms METH induces neurotoxicity via a combination of oxidative stress, mitochondrial dysfunction, excitotoxicity, and neuroinflammation