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Readers should interpret findings as hypothesis-generating

With high energy output from mitochondria comes higher free radical and ROS production and greater susceptibility to oxidative stresswhich is where glutathione comes in again.* The sirtuin SIRT3a longevity-related protein that requires NAD+ for proper functioningis also involved here, helping to maintain hearing during aging by promoting glutathione-mediated antioxidant defense systems

Neurotransmitter production (serotonin, dopamine)

Put simply, just because the door hasn't been kicked in yet does not mean you are on the right side of it

It increases the risk of localized immune modulation effects without added benefit