does glp 1 affect mental health Now, new research suggests that taking a GLP-1 could have a huge impact on your health—in a good way. Before we dive in, let's address the big question: No, doctors aren't Transformation 2.0: The GLP-1 RAs

Disclosures: Antonio Moreno: Nothing to Disclose, Thomas Issa: Nothing to Disclose, Douglas Farmer: Nothing to Disclose, Edward Wolfgang Lee: Nothing to Disclose 2224 STATIN USE IN CIRRHOSIS CAN DECREASE RISK OF PORTAL HYPERTENSION AND MORTALITY Muhammad Ali Butt 1 Taimur Muzammil 1 Rahul Karna 2 Himsikhar Khataniar 1 Nabeeha Mohy-ud-din 3 , 1 Allegheny General Hospital, Pittsburgh, PA, 2 University of Minnesota Medical Center, 3 Division of Gastroenterology, Hepatology and Nutrition, Allegheny Health Network, Pittsburgh, PA Background: MASLD related cirrhosis is one of the leading etiologies of liver disease, and these patients frequently have other comorbidities like atherosclerotic cardiovascular disease (ASCVD), hyperlipidemia (HLD), cerebrovascular disease (CVD), and diabetes mellitus (DM)

Disclosures: ATSUSHI UMEDA: EA Pharma Co., Ltd.: Employee, YASUKO OWADA: Nothing to Disclose, KENICHI FURIHATA: Kissei Pharmaceutical Company: Advisor, SHUICHI TSURUOKA: Nothing to Disclose, Atsushi Nakajima: Nothing to Disclose, RYOSUKE MIKAMI: Nothing to Disclose, MASAKAZE OAKU: Nothing to Disclose, TAKUYA YAMAMOTO: Nothing to Disclose, TETSUO YANO: Nothing to Disclose, YUJI KUMAGAI: Nothing to Disclose 593 DNA METHYLOME ANALYSIS REVEALS EPIGENETIC ALTERATION OF COMPLEMENT GENES IN ADVANCED MASLD Won Kim 1 Young Ho So 1 YONG JIN JUNG 1 Sae Kyung Joo 1 , 1 Boramae Medical Center Background: Blocking the complement system presents a promising strategy to impede the progression of metabolic dysfunction-associated steatotic liver disease (MASLD)

doi:10.1016/S0005-2736(98)00144-8 106

Taking it on an empty stomach with only plain water, and waiting at least 30 minutes before eating, maximises the amount of medication absorbed into the bloodstream

A useful next step will be to integrate behavioural, physiological, and neuroimaging data so that clinically meaningful response subtypes and their predictors can be identified more reliably, with potential relevance for more individualised treatment planning