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Clinical data shows that adding GIP agonism produces an additional 3-5% weight loss compared to GLP-1/GIP dual therapy alone

A mitochondrial switch ("SLC25A45") controls whether mitochondria burn fat or carbohydrate, and removing it (in mice) makes GLP-1 drugs stop working for fat loss entirely

Its broadly sweeping at the moment but will get stratified more and more by state of health, said Dr Ambrish Mithal, chairman and head of endocrinology and diabetes at Max Healthcare

Moreover, significant 11%12% relative risk reductions for allcause mortality and for heart failure hospitalisations have also been shown (Sattar et al., 2021)

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