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Tricyclic antidepressants can cause orthostatic hypotension and increase fall risk

Atorvastatin, by contrast, is metabolized predominantly by CYP3A4, with ortho- and para-hydroxylated active metabolites accounting for roughly 70% of circulating HMG-CoA reductase inhibitory activity [2]

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For osteoarthritis , NICE guidance (NG226) recommends a holistic approach: Education and self-management : Understanding the condition and strategies to manage symptoms Exercise and physical activity : Strengthening exercises, aerobic activity, and local muscle strengthening programmes Weight management : For those who are overweight or obese, structured weight loss programmes Pharmacological options : Topical NSAIDs as first-line