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Research ArticleGastroenterologyImmunology Free access | 10.1172/jci.insight.155338 1 Department of Pathology, Microbiology, and Immunology, 2 Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and 3 Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee, USA

One article proposed that excessive serotonin levels could explain classic symptoms of ME/CFS (433), as it would promote the release of excess CRH, and therefore cause chronic reactivation of the HPA axis (434)

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SMC3) [70]

[5] Some researchers combine both peptides to study how their effects might work together