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If you are concerned about any potential bruising or discomfort, the thigh may not be the best spot, especially as it can rub against clothing and cause irritation

Clean numbers across the board

Over time, this can lead to irregular periods, missed ovulation, or your period stopping altogether (called weight loss-related amenorrhea)

Concomitant conditions include uterine fibroids, polycystic ovarian syndrome, irritable bowel disease, migraines, fibromyalgia, anxiety, and depression, among others

Finally, geroscientists look for evidence in people that a drug developed for one condition also reduces the risk of other diseases and, ideally, lowers overall mortality