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It may achieve this by upregulating vascular endothelial growth factor (VEGF), an endogenous protein responsible for stimulating the growth of new blood vessels [4]

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Pan-cancer analysis of The Cancer Genome Atlas (TCGA) using the online Sangerbox 3.0 ( indicated that CRAT was also down-regulated in nine other cancer types, including Colon adenocarcinoma (COAD), Stomach and Esophageal carcinoma (STES), Uterine Corpus Endometrial Carcinoma (UCEC), Head and Neck squamous cell carcinoma (HNSC), Kidney renal clear cell carcinoma (KIRC), Thyroid carcinoma (THCA), Rectum adenocarcinoma (READ), Bladder Urothelial Carcinoma (BLCA) and Cholangiocarcinoma (CHOL) (Supplementary Fig