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for example, tirzepatide and GLP-1 behave similarly at the mGLP-1R, whereas tirzepatide is less potent at the mGIPR than mGIP

"Constipation from GLP-1s can be compounded by the fact that people are eating less," says Hamilton, "resulting often in less fiber consumption and less stool bulk overall." Many people also drink less fluid to avoid feeling overly full on GLP-1 medications, which can also lead to constipation

By contrast, the ATACH-II trial, which applied more aggressive BP reduction, failed to demonstrate significant benefits and raised concerns about renal adverse events 46

Being clear about this upfront helps set expectations that match reality, which in turn makes it easier to judge whether a product is genuinely working

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