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10.1021/acschembio.5b00245 39 DobrianA

In fact, the gene encoding the catalytic subunit of GCL ( GCLC ) is under the control of the antioxidant-responsive element (ARE), promoting the binding of the major detoxification-involved transcription factor (TF), nuclear factor erythroid 2-related factor 2 (Nrf2) [20]

Results : After 6 months, Mary reported significant improvements in skin elasticity, reduced wrinkles, and a more youthful appearance

Given that the pregnancy rates in women with PCOS who use CCs for OI are significantly lower than those who use CCs for LE [55], this could be a reason for the inconsistency between our study results and this meta-analysis