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Cells 2023;12, doi: Gonalves, S

Journal of Applied Genetics

Beyond sleep, DSIP has demonstrated a remarkably broad research profile: it modulates the HPA stress axis by reducing basal cortisol and ACTH levels, enhances endogenous opioid signalling to raise pain thresholds without tolerance development, and upregulates antioxidant defence enzymes including SOD, catalase, and glutathione peroxidase

The results: if there is an excess of vitamin B12 in the skin, the gene activity of these skin bacteria changes and they produce more of a molecule that fuels inflammatory processes

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