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3), the exact pattern of change over time cannot be accurately ascertained from the literature

Downstream Effects The released growth hormone then circulates to peripheral tissues where it exerts direct effects through binding to growth hormone receptors (GHR), and importantly stimulates the production of insulin-like growth factor 1 (IGF-1), particularly in the liver but also in many other tissues

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What insulin resistance feels like As oestrogen declines, cells throughout the body become less responsive to insulin

Heartburn medically referred to as gastro-oesophageal reflux occurs when stomach acid travels back up into the oesophagus, causing a burning sensation in the chest or throat