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These include interactions of the SNIP1 N-terminus with Smad4, a modulator of TGF- signaling 51,112 , and with RelA/p65, a transcription factor in the NF-B pathway 110 , as well as P-Thr-independent interaction of its C-terminal FHA domain with c-Myc, a protooncogene and transcriptional driver of cellular proliferation 52,53,55