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Key Contraindications (Both) Active malignancy or recent cancer history, pregnancy, breastfeeding, uncontrolled diabetes, severe pituitary disease

On the other hand, GPR65-expressing vagal afferents form mucosal endings in duodenal villi, such that they are selectively activated by duodenal infusion of nutrients [32]

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4 Tumor microenvironment, tumorigenesis and drug resistance Tumor microenvironment highly active cells, and in particular adipose tissue and TAMs, are potential determinant for a driving role of obesity and other risk factors in cancer development