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In a population-based study of 467 matched pairs of GLP-1RA users and non-users with T2D and liver cirrhosis, GLP-1RA use was associated with lower risks of death, cardiovascular events, decompensated cirrhosis, hepatic encephalopathy, and liver failure (101)

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While the underlying pathogenesis has not been elucidated in patients with isolated lesions, biallelic NF1 inactivation has been identified in melanocytes from CALMs in patients with NF1, and in McCuneAlbright syndrome, affected skin contains an activating mutation in the gene that encodes G s (see Chs 61 & 65)

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Cancer Cell 38 , 380399 (2020)