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We cloned the original sensor and the two computational designs into vectors containing a fragment of histone H2B for nuclear targeting in mammalian cells (Figure 1c)

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Comprehensive toxicology studies found no lethal dose even at extremely high levels (20 mg/kg intramuscularly in rats, equivalent to approximately 1,400 mg for a 155 pound human)

prausnitzii administration to CKD mice significantly lowered the abundance of toxin-producing Desulfovibrio and Collinsella