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In Mecp2-deficient mice, NTS neurons show significantly reduced amplitudes and frequencies of sIPSCs and mIPSCs, indicating impaired synaptic transmission, and decreased eIPSC amplitudes, though the paired-pulse ratio (PPR) remains unchanged, suggesting that postsynaptic mechanisms may contribute to the weakening of GABAergic inhibition

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These include relationship conflict, major life stressors, boredom, discrepant desire levels between partners, cultural/religious prohibitions and guilt, and subclinical depression, anxiety, and/or body image problems