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Description

Biophys Rev 13(5):697706

The SURPASS-2 trial showing tirzepatide achieving significantly greater HbA1c reduction and weight loss than semaglutide in T2DM patients, and the SURMOUNT trials showing up to 22% average body weight reduction in obese patients, have established tirzepatide as the clinical performance leader in the class

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The SELECT trial provided the first evidence of kidney protection with GLP-1RA treatment in individuals without diabetes, although this was a prespecified secondary endpoint