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Melatonin helps relax blood vessels and inhibit the sympathetic nervous system, both of which can reduce blood pressure

It may thus be suggested that direct exposure of the gut to the microbiome - capable of synthesizing thiamine antagonists or possessing thiamine-degrading thiaminase II - may first of all affect the gut, leading to gastrointestinal beriberi, especially under conditions of SIBO or other disturbances of the gut microbiome

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doi: 10.1523/JNEUROSCI.0227-18.2019 213 DuSItohNAskarinamSHillHArnoldAPVoskuhlRR

"The Vitamin G Content of Some Foods"