Symptoms of severe vitamin B12 deficiency can include visual disturbances, severe joint pain, paresthesia (tingling in the hands and feet), memory problems, depression, anxiety, poor muscle function, ataxia (impaired balance and coordination), changes in reflexes and even infertility
Hepatology 60 , 715735
If you are considering berberine, consult your GP or pharmacist first , particularly if you: Take prescribed medications for diabetes, cardiovascular disease, or other chronic conditions Are pregnant, planning pregnancy, or breastfeeding Have liver or kidney disease Are scheduled for surgery (berberine should be stopped at least 2 weeks before elective procedures) When to seek medical advice: Contact your GP if you experience persistent gastrointestinal symptoms, signs of hypoglycaemia (tremor, sweating, confusion, palpitations), unusual fatigue, or any concerning symptoms after starting berberine
We suppose the change is because the initial doses are enough to keep B12 levels within the desired range
Patients presenting with fatigue or brain fog: If the main complaint is systemic energy depletion or cognitive clarity, GHK-Cu is not the most targeted tool