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Rybelsus semaglutide tablets Highlights of Prescribing Information

And as the structure of tirzepatide degrades, its potency decreases

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Furthermore, to address concerns related to potential immortal time bias, we performed additional sensitivity analyses, varying the time window for tirzepatide initiation to assess whether different initiation periods influenced the results, and by resetting the index date to the HFpEF diagnosis date for both groups

The dose is also increased slowly over several months to reduce side effects, so the full effect builds over time rather than arriving at once